![]() ![]() ![]() Isothermal titration calorimetry (ITC) was used to explore the regulatory mechanism of CDs at all stages of HI fibrillation from the perspective of thermodynamics. ![]() ThT fluorescence analysis and transmission electron microscopy (TEM) characterization of the CDs showed the role of HI fibrillation from the perspective of the kinetics of HI fibrillation and regulation. L-Lysine CDs with a size of around 5 nm were synthesized and used to adjust and control the fibrillation process of HI. Due to changes in the spatial structure of HI, the fibrillation process of HI takes place in the body, which leads to a significant decrease in normal insulin levels. The fibrillation process of human insulin (HI) is closely related to the therapy for type II diabetes (T2D). ![]()
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